Pharmaceutical Chemical
Sorafenib Tosylate
Description
Use: Sorafenib is the first oral multi-kinase inhibitor that targets serine/ threonine and receptor tyrosine kinases in both the tumor cell and the tumor vasculature, said Ronald Bukowski, M.D., director of experimental therapeutics at the Cleveland Clinic Taussig Cancer Center in Ohio. In preclinical models, sorafenib targeted members of two classes of kinases, including RAF kinase, VEGFR-2, VEGFR-3, PDGFR-B, KIT, and FLT-3. These kinases are known to be involved in both tumor cell proliferation and tumor angiogenesis.
Chemical Name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-({4-[2-(N-methyl-carbamoyl)(4-pyridyloxy)]phenyl}-amino)carboxamide tosylate
CAS No.: [475207-59-1]
Appearance: Off-white crystalline powder.
Melting point:225 -235鈩?
Loss on Drying: 0.5%max.
Total Impurities: 1.0%max.
Purity by HPLC: 99.0%min.
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Shanghai Yingxuan Chempharm Co., Ltd.
Sorafenib Tosylate
Address: RM431 of BLDG 1,No.2588,Jinhai Road,Pudong New District, Shanghai,CN-201209,China,
Shanghai, Shanghai
China, 201209
Tel: :+86-21-60875125
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