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Raloxifene hydrochloride

82640-04-8

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Description

Raloxifene hydrochloride

Alias:[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride
CAS:82640-04-8
MF:C28H27NO4S.HCl;C28H28ClNO4S
MW:510.05
Density:1.285g / cm3
BP:687.5 ° C at 760 mmHg
FP:369.6 ° C
Vapor Pressure: 1.56E-19mmHg at 25 ° C
Assay:99%
Appearance:light yellow powder
Key words:Raloxifene hydrochloride 82640-04-8 corticosteroid-induced bone loss anti-estrogen breast cancer


Applications:

May prevent or treat corticosteroid-induced bone loss .American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents (e.g., bisphosphonates, calcitonin) or in whom such therapies are contraindicated.

Reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis.
Reduction in the incidence of invasive breast cancer in postmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial).No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial).Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established.

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